The dosage is currently the same for all breeds and sizes because when the effectiveness of a vaccine is tested and studied, it is ususlly on full size horses so the dosage is consistent. Many products say "the effectiveness of this product has not been evaluated in miniatures" on the labels. In order for the vaccine to be effective and legally valid (as with the rabies vac) the proper dose must be used.I agree, it seems odd that EVERY other drug or supplement is dosed by weight, but until trial studies are conducted with mini horses, it probably wont change. I have had horses get sick with the reconstitution live virus vaccines and usually they were aged horses. I would re evaluate your vaccine schedule and see if everything your sticking them with is absolutely necessary for one and I would ask the vet to see the vials he/she is drawing from. Are they ou dated or improperly mixed? Many modified live virus shots must be used immediately after mixing and if the vet pre mixes that could be causing problems. Some products warn about reactions, but if you're whole herd is reacting, I think something else is wrong. Maybe try a different brand of vaccine? Do your horses behave for shots? If not are they stressing out and thats causing colic? Or do their muscles ache from the shots and thats why they act miserable? My vet advises not to vaccinate old horses against rhino unless necessary as many have bad reactions. Did the vet hit a blood vessel? Did anyone get a fever/chills or sweats? Hitting a vessel will make them act sick too. Sorry your ponies aren't feeling good, hope they feel better soon.