Problem is Susanne, it is not safe with the accurate weights.
From what I've heard & read it is, provided that 1) the horse is not too thin (something to do with insufficient amounts of fat allowing the moxidectin to cross the brain barrier & cause neurological problems) and 2) the horse does not have a heavy worm load.
The horses (big and small) that I have heard of dying due to colic following administration of Quest died because they shed a very heavy worm load--the dying parasites caused lesions in the intestines when they let go en masse. The horse didn't have to be overdosed, it's just that the Quest is very effective & that isn't safe for horses that haven't been dewormed often enough or with an effective product prior to the use of Quest. Used properly and regularly I believe that it is safe--I know people that use it with no problems at all. I personally do not use it, because I do not have a scale & can not weigh my horses to make sure that I get the dosage right.
If the horse is overdosed (or if the horse is too thin at the time he is given the correct dosage) he is likely to have neurological problems--not colic.