Bluerocket
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Saw this on AOL --- hoping they will come up with a shot for a cure in my lifetime --
What do you think?
The Fat Virus: Fact or Fiction
Can You Catch Obesity Like a Common Cold?
By Liz Neporent
The extra doughnut you ate this morning might not be to blame for those extra pounds you're carrying. The culprit may be a virus. New evidence shows that it's possible to gain weight the same way you catch a common cold.
Can a virus make me fat?
It's possible. Scientists have long known that viruses can cause obesity in animals such as chickens, dogs and monkeys. Now, they think they're hot on the trail of one that causes obesity in humans. Studies on the adenovirus 36 (AD-36), a pesky microbe responsible for respiratory and eye infections, is thought to be the most likely candidate.
How can a virus cause weight gain?
The mechanism by which AD-36 and other possible fat bugs work isn't fully understood but recent studies have demonstrated that they're capable of transforming stem cells into fat cells with a Herculean ability for gathering and storing body fat. The virus may also trigger immature fat cells to multiply more quickly than normal and signal metabolism to put on the brakes so that the body burns calories more slowly.
How would I catch this virus?
Like any other virus, AD-36 could potentially be transmitted through sneezes, coughs or direct contact. Nikhil Dhurandhar, Ph.D., an associate professor at Louisiana State University's Pennington Biomedical Research Center thinks this might be one explanation for how human obesity has spread so quickly across the globe. However, he points out our understanding of these viruses is still quite limited. There isn't much evidence that edging away from the portly person in the elevator if he sneezes in your direction will help you avoid coming down with a case of fatness.
How can I find out if I have the "fat flu"?
Currently there's no test available. In the lab, researchers determine whether or not someone has been infected with AD-36 by scanning their blood for antibodies. Antibodies are a sort of biological footprint left behind by viruses when they invade the body and AD-36 is no exception. Dhurandhar conducted an investigation where 30 percent of obese subjects tested positive for the AD-36 antibodies compared to only 5 percent of normal weight individuals. Even when other factors such as lifestyle, genetics and family history were accounted for, the AD-36 positive subjects were among the most obese.
Isn't weight gain often caused by overeating and not enough exercise?
"For some reason people get stuck on the idea that you need to push yourself away from the table to lose weight," he says. It ruffles Dhrandhar's feathers when people make comments about overweight people simply needing more willpower. "With the entire world in the mist of an obesity epidemic, no one has definitively shown it is due to overeating and nothing else."
Is there a cure?
Despite the fact that he's not convinced that being overweight is clearly linked to overindulgence, Dhurandhar does acknowledge that it will be years before a fat vaccine may be developed. It would be an alternative to anyone with extra pounds to have a choice other than to watch what they eat and engage in regular exercise to help burn off excess calories. "We may have better treatments some day, or even a cure, but right now these are the best [treatments] we've got," he says.
SOURCE: Article below ---
Too fat? Common Virus May Be to Blame
Adult Stem Cells Turn Into Fat Cells
By JULIE STEENHUYSEN, Reuters
Posted: 2007-09-04 17:07:59
CHICAGO - A common virus caused human adult stem cells to turn into fat cells and could explain why some people become obese, U.S. researchers said.
The research builds on prior studies of adenovirus-36 -- a common cause of respiratory and eye infections -- and it may lead to an obesity vaccine, they said.
"We're not talking about preventing all types of obesity, but if it is caused by this virus in humans, we want a vaccine to prevent this," said Nikhil Dhurandhar, an associate professor at Pennington Biomedical Research Center at Louisiana State University System.
The virus adenovirus-36 or Ad-36, caused animals to pack on the pounds in lab experiments. "These animals accumulated a lot of fat," Dhurandhar said in a telephone interview.
Dhurandhar also has shown that obese people were three times more likely to have been infected with Ad-36 than thin people in a large study of humans.
Now, researchers in Dhurandhar's lab have shown that exposure to the virus caused adult human stem cells to turn into fat-storing cells.
Dr. Magdalena Pasarica, who led the study, obtained adult stem cells from fat tissue of people who had undergone liposuction. Stem cells are a type of master cell that exist in an immature form and give rise to more specialized cells.
Half of the stem cells were exposed to the virus Ad-36. After a week, most of the infected stem cells developed into fat cells, while the uninfected cells were unchanged.
Pasarica presented her findings at a meeting of the American Chemical Society in Boston.
"The virus appears to change their commitment to a fat storing cell," Dhurandhar said, adding that Ad-36 is just one of 10 pathogens linked to obesity and that more may be out there.
He acknowledged that some people might find it hard to believe that a virus could be responsible for obesity.
"Certainly overeating has something to do with gaining weight. No doubt about that. But that is not the whole truth," Dhurandhar said. "There are multiple causes of obesity. They range from simple overeating to genes to metabolism and perhaps viruses and infections."
Long term, he said he hoped to develop a vaccine and perhaps treatments for the virus. But first, he and colleagues need to better understand the role of Ad-36 in human obesity, he said.
Globally, around 400 million people are obese, including 20 million children under age 5, according to the World Health Organization.
What do you think?
The Fat Virus: Fact or Fiction
Can You Catch Obesity Like a Common Cold?
By Liz Neporent
The extra doughnut you ate this morning might not be to blame for those extra pounds you're carrying. The culprit may be a virus. New evidence shows that it's possible to gain weight the same way you catch a common cold.
Can a virus make me fat?
It's possible. Scientists have long known that viruses can cause obesity in animals such as chickens, dogs and monkeys. Now, they think they're hot on the trail of one that causes obesity in humans. Studies on the adenovirus 36 (AD-36), a pesky microbe responsible for respiratory and eye infections, is thought to be the most likely candidate.
How can a virus cause weight gain?
The mechanism by which AD-36 and other possible fat bugs work isn't fully understood but recent studies have demonstrated that they're capable of transforming stem cells into fat cells with a Herculean ability for gathering and storing body fat. The virus may also trigger immature fat cells to multiply more quickly than normal and signal metabolism to put on the brakes so that the body burns calories more slowly.
How would I catch this virus?
Like any other virus, AD-36 could potentially be transmitted through sneezes, coughs or direct contact. Nikhil Dhurandhar, Ph.D., an associate professor at Louisiana State University's Pennington Biomedical Research Center thinks this might be one explanation for how human obesity has spread so quickly across the globe. However, he points out our understanding of these viruses is still quite limited. There isn't much evidence that edging away from the portly person in the elevator if he sneezes in your direction will help you avoid coming down with a case of fatness.
How can I find out if I have the "fat flu"?
Currently there's no test available. In the lab, researchers determine whether or not someone has been infected with AD-36 by scanning their blood for antibodies. Antibodies are a sort of biological footprint left behind by viruses when they invade the body and AD-36 is no exception. Dhurandhar conducted an investigation where 30 percent of obese subjects tested positive for the AD-36 antibodies compared to only 5 percent of normal weight individuals. Even when other factors such as lifestyle, genetics and family history were accounted for, the AD-36 positive subjects were among the most obese.
Isn't weight gain often caused by overeating and not enough exercise?
"For some reason people get stuck on the idea that you need to push yourself away from the table to lose weight," he says. It ruffles Dhrandhar's feathers when people make comments about overweight people simply needing more willpower. "With the entire world in the mist of an obesity epidemic, no one has definitively shown it is due to overeating and nothing else."
Is there a cure?
Despite the fact that he's not convinced that being overweight is clearly linked to overindulgence, Dhurandhar does acknowledge that it will be years before a fat vaccine may be developed. It would be an alternative to anyone with extra pounds to have a choice other than to watch what they eat and engage in regular exercise to help burn off excess calories. "We may have better treatments some day, or even a cure, but right now these are the best [treatments] we've got," he says.
SOURCE: Article below ---
Too fat? Common Virus May Be to Blame
Adult Stem Cells Turn Into Fat Cells
By JULIE STEENHUYSEN, Reuters
Posted: 2007-09-04 17:07:59
CHICAGO - A common virus caused human adult stem cells to turn into fat cells and could explain why some people become obese, U.S. researchers said.
The research builds on prior studies of adenovirus-36 -- a common cause of respiratory and eye infections -- and it may lead to an obesity vaccine, they said.
"We're not talking about preventing all types of obesity, but if it is caused by this virus in humans, we want a vaccine to prevent this," said Nikhil Dhurandhar, an associate professor at Pennington Biomedical Research Center at Louisiana State University System.
The virus adenovirus-36 or Ad-36, caused animals to pack on the pounds in lab experiments. "These animals accumulated a lot of fat," Dhurandhar said in a telephone interview.
Dhurandhar also has shown that obese people were three times more likely to have been infected with Ad-36 than thin people in a large study of humans.
Now, researchers in Dhurandhar's lab have shown that exposure to the virus caused adult human stem cells to turn into fat-storing cells.
Dr. Magdalena Pasarica, who led the study, obtained adult stem cells from fat tissue of people who had undergone liposuction. Stem cells are a type of master cell that exist in an immature form and give rise to more specialized cells.
Half of the stem cells were exposed to the virus Ad-36. After a week, most of the infected stem cells developed into fat cells, while the uninfected cells were unchanged.
Pasarica presented her findings at a meeting of the American Chemical Society in Boston.
"The virus appears to change their commitment to a fat storing cell," Dhurandhar said, adding that Ad-36 is just one of 10 pathogens linked to obesity and that more may be out there.
He acknowledged that some people might find it hard to believe that a virus could be responsible for obesity.
"Certainly overeating has something to do with gaining weight. No doubt about that. But that is not the whole truth," Dhurandhar said. "There are multiple causes of obesity. They range from simple overeating to genes to metabolism and perhaps viruses and infections."
Long term, he said he hoped to develop a vaccine and perhaps treatments for the virus. But first, he and colleagues need to better understand the role of Ad-36 in human obesity, he said.
Globally, around 400 million people are obese, including 20 million children under age 5, according to the World Health Organization.